Structural insight into substrate and product binding in an archaeal mevalonate kinase.
Mevalonate kinase (MK) is a key enzyme of the mevalonate pathway, which produces the biosynthetic precursors for steroids, echofix spring reverb including cholesterol, and isoprenoids, the largest class of natural products.Currently available crystal structures of MK from different organisms depict the enzyme in its unbound, substrate-bound, and in